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KMID : 0376519920110010110
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Mental Health Research
1992 Volume.11 No. 1 p.110 ~ p.129
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Effect of Psychological Conflict Stress or Electric Shock Stress on the Immunologic Function in Rat
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Abstract
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Exposure to stress may suppress the immune system and contributes to the progress of certain diseases, such as neoplasia and infectious diseases. The purpose of this study was to examine the relationship between stress and immunological function
as
a
possible mechanism of stress and disease process. This study investigated how the psychological stress induced by avoidance-avoidance conflict model or physical stress of electric shock do impact the immune function, measuring proliferation and
interleukin-2(IL-2)production of rat splenic lymphocytes stimulated with various mitogens such as concanavalin-A (Con-A), phytohemagglutinin-M(PHA-M), and phorbol 12-myristate 13-acetate+calcium ionophore A23187(PMA+A23187). And it was also
measured
lymphokine activated killer(LAK)cell cytotoxicity against YAC-1 murine lymphoma cells.
In this experiment, female Sprag-Dawley rate were used as subjects. Animals were separated into four groups according to different stress conditions. Conflict group received psychological conflict stress with electric shock depending on the
coping
behavior and Yoked group was not in psychological conflict situation but received as same amount of electric shok as conflict group. Skinner box control group was immobilized without electric shock shock and Home cage control group had no stress
condition.
@ES The results are as follows ;
@EN 1) there is significant decrease in lymphocyte proliferation and LAK cell cytotoxicity of Yoked group compared with those of Skinner box control group at high current condition, but not at low current condition.
2) There is significant decrease in IL-2 production of Yoked group in comparison with that of Skinner box control group.
3) There is more significant decrease in lymphocyte proliferation and LAK cell cytotoxicity of Conflict group compared with those of Yoked group regardless of the high or low current condition.
4) There is significant decrease in IL-2 production of Conflicat group in comparison with that of Yoked group.
This results suggest that psychological stress could reduce the immune function more profoundly than physical stress and also means the importance of coping and appraisal in the stress-immunology rela tionship.
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KEYWORD
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